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CAS No. 150378-17-9 | Indinavir

Name: Indinavir CAS No. 150378-17-9 MF:C36H47N5O4 MW:613.79 Purity:98% Package: 5mg,25mg,200mg,500mg,1g Worldwide Delivery

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Product introduction

Introduction and application of CAS No. 150378-17-9 | Indinavir

Synonyms:(1(1S,2R)5(S))-2,3,5-TRIDEOXY-N-(2,3-DIHYDRO-2HYDROXY-1H-INDEN-1-YI)-;

(1(1S,2R),5(S))-2,3,5-Trideoxy-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-(2-(((1,1-dimethylethyl)amino)carbonyl)-4-(3-pyridinylmethyl)-1-piperazinyl)-2-(phenylmethyl)-D-erythro-pentonamide;

[I(1S，2R)，5(S)]-2，3，5-Trideoxy-N-(2，3．Dihydro-2-hydrox-Lh-inden-1-y1)-5-[2-[[(1，1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-D-erythro-pentonamide;

Specification:

ITEMS	SPECIFICATION
CAS	150378-17-9
MF	C36H47N5O4
MW	613.79
Melting point	153-154°
Boiling point	877.9±65.0 °C
Density	1.25±0.1 g/cm3
Acidity coefficient	3.8-6.2
Solubility	Soluble in dimethyl sulfoxide
Storage condition	Store at -20°C

Biological activity:

Indinavir (MK-639; L735524) is an HIV protease inhibitor with good oral biocompatibility.

Chemical Properties:

Monohydrate: Crystallizes from wet ethyl acetate or isopropyl acetate. It loses water below 100°C and recrystallizes to obtain anhydrous substance with a melting point of 153-154°C; the melting point of the second anhydrous substance is 167.5-168°C. Solubility in water (mg/m1): 0.015 (no buffer), >1.5 (pH=4.0). [α]D22+24.1. (C=0.0133, chloroform). Indinavir Sulfate: C36Ha7N5O4?H2SO4. [157810-81-6]. Appears as monoethanol compound. Crystallized from absolute ethanol, the softening point is 135°C and the melting point is 150~153°C (decomposition). Loss of ethanol or formation of hydrates upon exposure to moisture.

use:

Antiviral drugs. It is a novel hydroxyaminopentanamide HIV-1 protease inhibitor used to treat AIDS.

production method:

At -50°C, add the weak base Lithium hexamethyldisilazide (LHS) to the solution of compound (I) and (S)-(+)-anhydroglycerol tosylate (II), and then raise the temperature to -25°C to react Compound (III) can be obtained in 72% yield. (III) and compound (IV) were refluxed and condensed in isopropyl alcohol (IPA), and then 6 mol/L hydrochloric acid was added to remove the protecting group on N to obtain compound (V). Finally, it reacted with 3-pyridinecarboxylic acid chloride to obtain the product, with a yield of 71% based on compound (III).

Package and transportation :

Package: 5mg,25mg,200mg,500mg,1g